|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
While the patient with Behcet's had low protein level, another patient with AAA had high of MMP-9 level.
|
20842516 |
2011 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
When Angptl2-deficient mice were used in the mouse model, they showed decreased AAA development compared with wild-type mice, as evidenced by reduction in aneurysmal size, less severe destruction of vessel structure, and lower expression of proinflammatory cytokines and matrix metalloproteinase-9.
|
22556334 |
2012 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
We therefore found no evidence that MMP-9 is a marker of susceptibility for AAA.
|
17223007 |
2007 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
We hypothesized that LRP1 downregulation may be mediated by microRNA (miR) and that LRP1 may function as a scavenger of matrix metalloproteinase-9 (MMP-9), a well-known protease for degradation of extracellular matrix proteins at the aortic wall for AAA pathogenesis.
|
26781079 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We further demonstrated an association between osteogenesis and inflammation; indeed, ha-MSCs cultured with either cytokines (TNF-α, IL-1β) or AAA-PBMCs showed increased expression of MMP-9 and osteogenic markers, to the detriment of the adipogenic regulator PPAR-γ.
|
28446225 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We also assessed the potential association between 2 functional single nucleotide polymorphisms in the genes MMP9 (-1561C/T; rs3918242) and MMP13 (-77A/G; rs2252070), and the presence of large AAAs.
|
29739236 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Transfection of the Egr-1 specific synthetic DNA enzyme EDRz significantly reduced AAA following elastase infusion in rats, at least in part due to the decreased expression of downstream MMP-2 and MMP-9.
|
29977360 |
2018 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
This study provides further evidence to support the role of MMP-9 in the pathogenesis of AAA, and indicates that the MMP9 C-1562T functional polymorphism may represent a genetic component contributing to susceptibility to this vascular disease.
|
14681642 |
2003 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
These studies have helped us identify genes that are essential to the development of AAAs (such as MMP9, IL6, and AT1R) and to reveal other genes that may be dispensable in aneurysm formation.
|
17182923 |
2006 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
These observations indicated that Imatinib prevents aneurysm progression by inhibiting STAT3-mediated MMP9 expression and activation, suggesting a new application of Imatinib on AAA clinical therapy.
|
31325435 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
These findings suggest that macrophage-derived MMP-9 and mesenchymal cell MMP-2 are both required and work in concert to produce AAA.
|
12208863 |
2002 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
There was a significant increase in the level of MMP-9 mRNA in AAA specimens (occlusive, 16.8 +/- 3, n = 3; donor, 5.7 +/- 1.2, n = 6; AAA, 56.7 +/- 11, n = 15, p = 0.0069).
|
9588507 |
1998 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The findings promoted us to test whether aneurysmal prone factors could up-regulate the expression of MMP-2 and MMP-9 through aberrantly increased HIF-1α and promote AAA development.
|
27363580 |
2016 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The combined approach of direct experimental confirmation of the functional alterations of MMP-9 SNPs and logistic-regression analysis revealed significant association between MMP-9 genotype and abdominal aortic aneurysm.
|
22942228 |
2012 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the study was to investigate the effect of functional polymorphisms in promoters of the MMP-2 (-1306 C > T), MMP-3 (-1171 5A > 6A), MMP-9 (-1562 C > T), MMP-12 (-82 A > G), TIMP-1 (-372 C > T), and PAI-1 (-675 4G > 5G and -847 A > G) genes on the growth rate of small abdominal aortic aneurysms.
|
17182940 |
2006 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The adjusted recessive models also showed increased risk for AAA for the carriers of MMP-9 T allele (OR = 15.69, 95% CI = 1.40-175.41, p = 0.025).
|
27533781 |
2016 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results indicated that nifedipine inhibits the progression of experimental AAA possibly through suppression of NF-kappaB and MMP-9 activity, leading to protective effects against AAA beyond those associated with blood pressure lowering.
|
18204791 |
2008 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Sunitinib therapy substantially mitigated both AAA formation and further progression of established AAAs, attenuated aneurysmal aortic MMP2 (matrix metalloproteinase) and MMP9 protein expression, inhibited inflammatory monocyte and neutrophil chemotaxis to VEGF-A, and reduced MMP2, MMP9, and VEGF-A mRNA expression in macrophages and smooth muscle cells in vitro.
|
31294623 |
2019 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Several studies of gene polymorphisms support MMP-9 for TAA and MMP-3 for AAA as potentially important factors.
|
28413030 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
RELMβ gene deficiency significantly decreased AAA incidence and severity, which was associated with reduced macrophage accumulation and decreased expression of proinflammatory cytokines (monocyte chemoattractant protein 1 and interleukin 6), matrix metalloproteinase 2 (MMP-2) and MMP-9 in the aortic wall.
|
29262630 |
2017 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Quantitative competitive reverse transcription-polymerase chain reaction and gelatin zymography showed increased MMP-9 mRNA and protein in both AAA and AOD tissues compared with those in control tissue, but there was no significant difference between AAA and AOD.
|
9763536 |
1998 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Preoperative treatment with doxycycline was associated with a 3-fold reduction in aortic wall expression of MMP-2 and a 4-fold reduction in MMP-9 (p < 0.05 compared to untreated AAA).
|
10415728 |
1999 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of the matrix metalloproteinase 9 gene and abdominal aortic aneurysm.
|
18763261 |
2008 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
Biomarker
|
disease |
BEFREE |
Plasma protein levels were significantly elevated for osteopontin, MMP-2, and MMP-9 in the samples of ascending and abdominal aortic aneurysm group compared with controls.
|
22571802 |
2013 |
|
Aortic Aneurysm, Abdominal
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Our results suggest that MURC/Cavin-4 in VSMCs modulates AAA progression at the early stage via the activation of JNK and MMP-9.
|
28433630 |
2017 |